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ea0099p141 | Reproductive and Developmental Endocrinology | ECE2024

Copeptin and oxytocin in MDMA-induced hyponatremia:incidence and severity, mechanisms of action, and the effect of fluid restriction

Atila Cihan , Straumann Isabelle , Vizeli Patrick , Beck Julia , Monnerat Sophie , Holze Friederike , Liechti Matthias , Christ-Crain Mirjam

Importance: 3,4-Methylenedioxymethamphetamine (MDMA, ecstasy) is a trending recreational drug but also has potential to enter clinical practice. Acute hyponatremia is a serious complication arising from ingesting even a single dose of MDMA. The assumed aetiology is a vasopressin release inducing the syndrome of inappropriate anti-diuresis combined with increased thirst causing polydipsia and thus water intoxication.Methods: Pooled analysis of...

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Copeptin and oxytocin in MDMA-induced hyponatremia:incidence and severity, mechanisms of action, and the effect of fluid restriction

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